Specifically, the revised Sapporo APS classification criteria issued in 2006 required positive lupus anticoagulant (LAC) test and/or the presence of aPLs (anti-cardiolipin antibodies (aCL) or anti-β2-glycoprotein I antibodies (aβ2GPI) [of IgG or IgM isotype]) with titers exceeding either the 99th percentile of healthy controls or a moderate level of 40 in the traditional unit of so-called “GPL/MPL” [2]. Here, CD40LG is linked to autoimmune polyendocrinopathy.