In this study, we selected nucleophosmin (NPM1) present in the GC region [23, 24] and fibrillarin (FBL) present in the DFC region [24, 25, 26] of the nucleolus and analyzed their cellular localization, expression in PCa patient specimens, and role in regulating proliferation, migration and invasion, and nucleolar morphology. This evidence concerns the gene NPM1 and posterior cortical atrophy.