CD300A and acute kidney injury: We next analyzed AKI, in which the renal arteries were clamped bilaterally for 15 minutes followed by reperfusion (biIRI) in Cd300afl/fl and Cd300afl/flLyz2-Cre mice (Figure 2A), in which CD300a expression is lacking on the phagocytes in the kidney (Supplemental Figure 2A); this is a similar expression profile to that of Cd300a−/− mice in the heart.