Recent studies have reported that SiglecFhi neutrophils are elicited at the injured tissue by DAMPs and have a pathogenic function to induce fibrosis by producing profibrotic or proinflammatory cytokines such as TGF-β, TNF-α, and IL-1β, and also by directly producing collagen I in a mouse model of CKD (12). This evidence concerns the gene IL1B and chronic kidney disease.