Since the SiglecFhi and SiglecFlo neutrophils were lower and higher, respectively, in Cd300afl/flLyz2-Cre mice than in Cd300afl/fl mice in the kidney after biIR, CD300a on neutrophils, as well as tissue-resident macrophages, likely plays an important role in the development of AKI and subsequent renal fibrosis. The gene discussed is CD300A; the disease is acute kidney injury.