To clarify the role of TNAX103 in the development of AKI after IRI, human CD34+ stem cells were transplanted into NOD/SCID mice deficient in the common γ chain of the IL-2 receptor (NOG mice) with transgenic expression of human GM-CSF and IL-3 (named NOG-EXL mice) (Figure 7D). The gene discussed is IL3; the disease is acute kidney injury.