TGFB1 and chronic kidney disease: Recent studies have reported that SiglecFhi neutrophils are elicited at the injured tissue by DAMPs and have a pathogenic function to induce fibrosis by producing profibrotic or proinflammatory cytokines such as TGF-β, TNF-α, and IL-1β, and also by directly producing collagen I in a mouse model of CKD (12).