Tissue slices from IBD patients showed increased baseline secretion of several proinflammatory mediators, including the Th17‐related cytokines IL‐17A (log2FC: 4.38), IL‐22 (log2FC: 4.24), and Th1‐related cytokine IL‐12p70 (log2FC: 3.75) as well as several mediators associated with the recruitment of innate immune cells, such as IL‐8 (log2FC: 6.59), MCP‐1 (log2FC: 1.26) and ENA‐78 (log2FC: 4.27). Here, CXCL5 is linked to inflammatory bowel disease.