Further, we observed an increased basal release of pro‐inflammatory cytokines, for example, IL‐22, IL‐12p70, and ENA‐78, aligning with the upregulation of genes involved in IL‐17 signaling, IFN signaling, and neutrophil chemotaxis in IBD‐derived PCIS ex vivo. This evidence concerns the gene CXCL5 and inflammatory bowel disease.