LPS‐stimulated tissue from IBD patients showed, compared with LPS‐stimulated tissue from non‐IBD patients, increased secretion of mediators associated with the recruitment of innate immune cells and tissue repair, such as TNF‐α (log2FC: 4.4), IL‐22 (log2FC: 2.1), IL‐18 (log2FC: 2.4), TRAIL (log2FC: 1.85), and ENA‐78 (log2FC: 1.82), but, similar to unstimulated conditions, decreased secretion of IL‐31 (log2FC: −0.64). This evidence concerns the gene TNFSF10 and inflammatory bowel disease.