Upregulation of SYT1 and syntaxin in lower grades may presage the tumor engagement with neural circuits, while their fluctuations and the consistent downregulation of V-ATPase and neurotransmitter transporters in higher grades reflect a shift toward a more malignant strategy– one that forsakes normal homeostasis in favor of a hostile, pro-tumor environment. The gene discussed is SLC6A2; the disease is neoplasm.