Three generations of anti-FRα-CAR-T cells, namely, FRα–ζ (first generation), FRα–28ζ (second generation) and FRα–28BBξ (third generation), all of which selectively eliminate the FRα-positive human ovarian cancer cell lines SK-OV-3 and A2780 [87]. Here, FOLR1 is linked to ovarian carcinoma.