Furthermore, lung cancer patients with high levels of PDE1A in their tumors had shorter overall survival than those with low PDE1A expression, indicating that PDE1A overexpression was correlated with a poor prognosis in lung cancer patients (Figure 1E; Rousseaux et al., 2013; Goswami and Nakshatri, 2014). This evidence concerns the gene PDE1A and lung carcinoma.