To better explore the mechanism of PDE1A in NSCLC progression, bioinformatic analysis of PDE1A coexpressed genes was performed, which revealed that PDE1A might be involved in the JAK/STAT3, Hedgehog, and TGF-β pathways in NSCLC (Figure 5A). The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.