TARDBP and amyotrophic lateral sclerosis: Current cellular models aimed at investigating TDP43 mislocalization involve mutating the TDP43 nuclear-localization signal, using mutant versions identified in familial ALS patients, or the use of pharmacological agents to induce stress (Barmada et al., 2010; Zuo et al., 2021; Ziff et al., 2023; Walker et al., 2015).