ADAMs are multidomain transmembraneproteins that are critical in proteolysis, cell adhesion, and cellmigration, which are essential for immune regulation and inflammation., ADAM15 has been implicated in the development of several diseases,such as cancer, Alzheimer’s disease, and chronic immune disorders.,, FGF-5 plays a vital role in cellproliferation and cell differentiation and has been implicated incancer formation and tissue regeneration.−,  CD5 is importantfor lymphocyte selection and immune tolerance. Here, ADAM15 is linked to early-onset autosomal dominant Alzheimer disease.