GSDMD and acquired polycythemia vera: While the percentage and number of NK cells were markedly increased in WT mice at 48 h post-PRV infection relative to 0 h, they decreased in WT mice at 72 and 96 h post-PRV infection relative to 0 h; but the percentage and number of NK cells were significantly increased in Gsdmd−/− mice at 48 and 72 h post-PRV infection relative to 0 h, and no significant difference in Gsdmd−/− mice at 96 h post-PRV infection relative to 0 h (Fig. 4D and E).