Cer accumulationhas been also linked to neurodegenerative diseases and neural toxicity, and are involved inseveral cellular processes, including apoptosis, oxidative stress,and neural inflammation., For instance, in glialcells, Cer accumulation increases reactive oxygen species (ROS) production and activates NF-kB signaling in microglia,promoting an inflammatory response. This evidence concerns the gene NFKB1 and neurodegenerative disease.