Here, the mouse prostate cancer bone‐metastatic cell line RM1(BM), with Aldh1a3 gene knockdown and previously reported high metastatic potential, was used.[42] Intracardiac injection with RM1(BM) shAldh1a3 cells in immunocompetent mice exhibited a higher incidence of bone marrow metastases compared to those injected with the parental RM1(BM) cells treated with shNS (non‐silencing shRNA) (Figure 3bI&II). The gene discussed is ALDH1A3; the disease is Familial prostate cancer.