In conclusion, we report a unique case of a patient who presented with secondaryamenorrhea, prediabetes, and secondary osteoporosis and was found to have ade novo variant in exon 1 of the LMNA gene.This case demonstrates clinical overlap with Malouf syndrome while also exhibitingadditional progeroid features, representing a distinct laminopathy. This evidence concerns the gene LMNA and laminopathy.