Comparison between peritoneal tissue samples (lesions, peritoneal wall from controls and endometriosis, mesothelial cells) identified alterations in the metabolic response of mesothelial cells in endometriosis patients [101] and increased expression of genes implicated in pain signaling including ion channels (TPV1, TRPA1, P3RX3, [102] and growth factors) [39]. Here, TRPA1 is linked to endometriosis.