Persistent mucocutaneous candidiasis in patients with autoimmune endocrinopathies warrants evaluation for underlying IEI: while candidiasis is common in individuals with diabetes, recurrent or treatment-refractory infections – particularly in the presence of additional autoimmune conditions – should prompt consideration of IEI, including STAT1 gain-of-function mutations. Here, STAT1 is linked to Candidiasis, Invasive.