Profiling proinflammatorycytokines like interleukin-6 (IL-6) inbody fluids offers critical insights into immune responses relatedto conditions such as sepsis, myocardialinfarction, COVID-19, and neurodegenerative disorders. Monitoring IL-6 in the whole blood, serum, or plasma is particularlyvaluable for assessing the inflammation severity, for prognostication, and for identifying subphenotypes with the potential to guide novel therapies. This evidence concerns the gene IL6 and Sepsis.