Proteomic analysis of five OPMD cases identified dermokine, tryptase, and matriptase as potential biomarkers, further examined through clinical, histopathological, and immunohistochemical analyses across NM, OPMD, and OOSCC tissues.<h4>Results</h4>Females comprised 52% of the OPMD group, whereas males accounted for 87.5% of OOSCC cases. The gene discussed is ST14; the disease is oculopharyngeal muscular dystrophy.