The R337H variant was identified in patients with Li–Fraumeni‐like syndrome, and this mutation is associated with an increased risk for adrenocortical carcinoma.[3, 6] The R337H substitution strongly destabilizes the homo‐tetrameric structure,[12] but our FRET analysis indicated that the R337H showed about 70% levels of homotetramer formation in comparison to what is measured for the WT p53 homotetramer in cells. Here, TP53 is linked to adrenal cortex carcinoma.