The overexpression or gene amplificationof the HER2 receptor,a member of the ErbB receptor family, is associated with an aggressivebreast cancer phenotype and has predictive value for other tumors,including lung, ovarian, colon adenocarcinomas, and salivary glandcancers.−,  HER2 amplification leads to self-dimerization ordimerization with other ErbB receptors, resulting in continuous activationof HER signaling pathways. Here, ERBB2 is linked to cancer.