It has been proven that abnormalities in bone metabolism that translate into reduced bone mineral density (BMD) and deregulated circulating levels of indexes of bone metabolism, such as bone alkaline phosphatase (BAP), C-terminal cross-linked telopeptide of type I collagen (CTX-I), osteocalcin (OC) are associate with metabolic syndrome in overweight PCOS adolescents (12). The gene discussed is BGLAP; the disease is polycystic ovary syndrome.