Cyp1b1 and Ephx1, which are involved in metabolism of xenobiotics by cytochrome P450, were upregulated in the PCOS rats but recovered in the NaBu rats, whereas Aldh3b1 and Idh1 were downregulated in the PCOS rats and recovered in the NaBu rats. The gene discussed is EPHX1; the disease is polycystic ovary syndrome.