(10) reported a significant correlation between homozygous and compound heterozygous ABCC8/KCNJ11 mutations and an increased risk of thrombosis (R2 = 0.40, P = 0.001), suggesting that severe CHI cases carrying these genetic variants may be predisposed to thrombotic events (11). Here, KCNJ11 is linked to congenital isolated hyperinsulinism.