c-Kit, ERG1, IGF-1, p-PI3K, p-Akt, camp, PKA, CaMKII, P-CaMKII, type I and III collagen in gastric smooth muscle tissue, interstitial cells of Cajal (ICC), PGP9.5, GRP78, CHOP, ATF6, Caspase-12, TMEM16A, ROCK2, nNOS, SYN, SIRT1, Bach1, c-kit, HO-1, CD8, RhoA, MYPT1, p-MYPT1, HIF⁃1α, VEGF, and c-fos, GFAP. The gene discussed is RHOA; the disease is intrahepatic cholangiocarcinoma.