Studies show that aerobic exercise can alleviate cardiac hypertrophy and inflammation by upregulating miR-574-3p and inhibiting the IL-6/JAK/STAT pathwa (Chen et al., 2024); Moreover, aerobic exercise can reduce the activity of the JAK-STAT pathway through the potential target NR1D1, thereby improving muscle function in mice (Yao et al., 2024). This evidence concerns the gene SOAT1 and cardiac hypertrophy.