CD274 and melanoma: Studies have shown that, in melanoma mice, the combination of aerobic exercise and anti-PD-L1 treatment leads to significantly better tumor suppression effects compared to the control grou (Yan et al., 2023); Moreover, studies on a lung cancer mouse model have shown that aerobic exercise can significantly reduce the PD-L1 mRNA levels in lung cancer mice, further improving the expression levels of immune checkpoint proteins in the tumor tissue and intervening in tumor growth (Ge et al., 2022).