The elevated lactate levels in tumor cells are not only closely related to the Warburg effect but also contribute to the abnormal expression of various glycolytic enzymes and monocarboxylate transporters, such as lactate dehydrogenase A (LDHA), MCT1, and MCT4, through the upregulation and activation of HIF-1α and c-Myc. This evidence concerns the gene MYC and neoplasm.