Alternative CRISPR-based technologies that offer greater specificity and precision are also being investigated such as prime editing in the treatment of autosomal recessive chronic granulomatous disease to correct a two nucleotide deletion in the NCF1 gene encoding p47phox protein, as demonstrated by 87 % of CD34+ LT-HSCs with at least a single edited allele sixteen weeks post-murine transplantation [40]. Here, NCF1 is linked to granulomatous disease, chronic, autosomal recessive, 5.