CHI3L1 is overexpressed in cancer38 and relates to worse prognosis, macrophage recruitment and angiogenesis.39 Osteopontin is also associated with cancer, metastatic processes40 and immunosuppression, regulating M2-like polarization of microglia.41 Our experiments confirm their powerful capacity to induce neovascularization and, for the case of osteopontin, direct M2 macrophage polarization and migration. The gene discussed is SPP1; the disease is cancer.