CHI3L1 is overexpressed in cancer38 and relates to worse prognosis, macrophage recruitment and angiogenesis.39 Osteopontin is also associated with cancer, metastatic processes40 and immunosuppression, regulating M2-like polarization of microglia.41 Our experiments confirm their powerful capacity to induce neovascularization and, for the case of osteopontin, direct M2 macrophage polarization and migration. This evidence concerns the gene CHI3L1 and cancer.