Further, Lin et al. (28) hold that the perivascular AQP-4 depolarization and intracranial hypertension after ischemic stroke, leading to increased resistance of ISF outflow pathway, great changes of the clearance efficiency have been made in GS, caused by mainly involving the abnormal protein deposition, may be related to vascular dementia (29). Here, AQP4 is linked to ischemic stroke.