IL6 and Mental deterioration: Among these markers are Interleukin-1α (IL-1α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), and CCL2, contributing to microglial activation, synaptic irregularities, cognitive decline, and hindered adult neurogenesis (7, 8).