Hesperidin (20, 50, and 100 mg/kg orally for 28 days) reduces depression-like behaviors and expression of IL-1β, IL-6, TNF-α, NLRP3, caspase-1 in the prefrontal cortex and microglia in chronic unpredictable mild stress (CUMS)-induced rats (80). The gene discussed is IL1B; the disease is major depressive disorder.