Hesperidin (20, 50, and 100 mg/kg orally for 28 days) reduces depression-like behaviors and expression of IL-1β, IL-6, TNF-α, NLRP3, caspase-1 in the prefrontal cortex and microglia in chronic unpredictable mild stress (CUMS)-induced rats (80). Here, IL6 is linked to major depressive disorder.