These include PD-L1 and TRAIL, two pro-inflammatory proteins whose downregulation has beneficial effects in models of stroke (Bodhankar et al., 2015; Hoffmann et al., 2009) and CCL23, a chemokine that induces further expression of inflammatory proteins in a feed-forward mechanism (Simats et al., 2018). The gene discussed is TNFSF10; the disease is stroke disorder.