MAPT and Parkinson disease: Analysis of global methylation patterns within the MAPT gene promoter region (CpGs 1–11) and the SNCA gene intron 1 (CpGs 1–7 and CpG 25) revealed significant hypomethylation in the PD group compared to controls (MAPT, p = 0.0019; SNCA, p = 0.000069), as illustrated in Figure 2.