MMP-10 (stromelysin-2) is a proteolytic enzyme that degrades multiple components of the extracellular matrix.14 It is elevated in induced sputum and bronchoalveolar lavage fluids of pulmonary tuberculosis patients compared to controls,15 and has also been implicated in host immune responses to other pathogens.16 Furthermore, in HIV co-infected TBM patients, CSF MMP-10 levels increased before the onset of immune reconstitution inflammatory syndrome following antiretroviral therapy,17 suggesting a role in TBM-related immunopathology. This evidence concerns the gene MMP10 and pulmonary tuberculosis.