Disruption of these barriers is a hallmark of neuroinflammation during CNS infections, and in vitro studies have implicated MMPs in blood–brain barrier disruption.19 Numerous MMPs have been shown to be elevated in TBM18 and we observed that CSF MMP-10 concentrations correlated with CSF total protein, a surrogate for blood–CSF barrier dysfunction, which correlates to CSF/serum albumin quotient.12 This supports the hypothesis that MMP-10 may contribute to TBM immunopathology by inducing barrier disruption. Here, MMP10 is linked to meningeal tuberculosis.