PRDX5 and cancer: Similarly, inhibitors of glutathione peroxidase (GPX) and thioredoxin reductase (TXNRD) shift cellular redox balance toward oxidative stress, triggering cancer cell death (Sun Y. et al., 2021; Tan et al., 2022; Augello et al., 2023; Liu et al., 2023; Peng et al., 2023).