CDH1 and cancer: For instance, zinc finger family transcription factors Zeb1 and Zeb2 bind to the promoter of the E-cadherin coding gene CDH1, repress the expression of E-cadherin, and activate all three types of EMT, that are tissue development, fibrosis, and cancer progression (Sánchez-Tilló et al., 2010; Debnath et al., 2022; Kinouchi et al., 2024).