The injury is supported by the finding of increased serum endothelial cell damage biomarkers, such as intercellular adhesion molecular-1 (ICAM-1), soluble endothelial cell leukocyte adhesion molecule 1, endothelin, von Willebrand factor-antigen and endothelial glycocalyx component syndecan-1 (SDC-1) in the heat stroke models of experimental animals and patients (Tong et al., 2014; Umemura et al., 2018). The gene discussed is SDC1; the disease is Heat Stroke.