Biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), Activin A, CD163, and Cystatin C have proven to be reliable for the early diagnosis of CKD in this context (Conticini et al., 2023), thereby reinforcing the crucial connection between immune dysregulation, and renal damage across different conditions. The gene discussed is CST3; the disease is chronic kidney disease.