Figure 4 illustrates how HNRNPA2B1 may influence pulmonary hypertension by regulating PASMCs, PAECs, and macrophages. To date, only one study has demonstrated the role of HNRNPA2B1 in MCT-induced PH, though the specific mechanisms remain unexplored. Numerous studies suggest that HNRNPA2B1 is involved in cell proliferation, apoptosis, and PASMC metabolism (Figure 1); however, its exact mechanism of action in PASMCs is still unclear. Here, HNRNPA2B1 is linked to pulmonary arterial hypertension.