IL1A and major depressive disorder: In the central nervous system, besides its conventional roles in the immune responses (Dubé et al., 2005) (Rothwell, 2003), IL-1 signaling is involved in pathological conditions such as neurodegeneration (Shaftel et al., 2008), anxiety disorders and major depression (Murray et al., 2013; DiSabato et al., 2021) as well as stress-induced psychopathologies (Goshen et al., 2009).