TCHP and gastric cancer: Exosomal NEAT1 has been shown to contribute to the tumorigenic characteristics of gastric cancer (GC) in both in vivo and in vitro studies, not only by suppressing p53 through UBE3C and RAD18, but also by downregulating the tumor suppressor protein TP53INP1, thereby stimulating epithelial-mesenchymal transition (EMT) (77).