This study aims to address these gaps by: (1) analyzing the immunohistochemical expression patterns of TLR4 and MyD88 proteins in colorectal adenomas and carcinomas, (2) investigating single nucleotide polymorphisms (SNPs) in TLR4 and MyD88 genes, and (3) evaluating their associations with clinicopathological features and protein expression. This evidence concerns the gene TLR4 and colorectal adenoma.