CSF3 and acute graft versus host disease: Mixtures of granulocyte colony-stimulating factor (G-CSF) primed BM (G-BM) plus G-CSF mobilized peripheral blood grafts (G-PB) have successfully introduced T-cell hyporesponsiveness, promote polarization of T cells from Th1 to Th2, and provided protection against acute graft-versus-host disease (aGvHD) (55).