(2021) first demonstrated that Fusobacterium nucleatum activates TLR4/NF-κB/miR-1322 signaling cascade to upregulate CCL20, driving monocyte differentiation into CCR6+ TAMs, which subsequently induce M2 polarization through IL-6/STAT3 pathway, upregulating Arg1 levels and down regulating iNOS levels, ultimately enhancing CRC liver metastasis (102, 103). Here, NFKB1 is linked to colorectal carcinoma.