In GC models, lactate-induced H3K18 lactylation upregulates VCAM1 transcription, activates AKT-mTOR signaling, enhances CXCL1 secretion, and expands GC-derived mesenchymal stem cells and M2 macrophages, collectively accelerating gastric cancer progression (55). This evidence concerns the gene CXCL1 and gastric cancer.