Additionally, gut microbiota-derived lactate reprograms ATM glycolysis, induces RIG-I K852 lactylation to inhibit RIG-I-MAVS-NF-κB signaling, and synergizes with cathepsin K to establish an immunosuppressive niche favoring CRC metastasis (176, 177). This evidence concerns the gene NFKB1 and colorectal carcinoma.