For example, HMGA2 mediated the occurrence of triple-negative breast cancer by activating the NF-kB/IL-6/IL-8/STAT3 axis (37); HMGA2 activated the mTOR signaling pathway to inhibit ferroptosis, thereby enhancing the death resistance of pancreatic cancer and reducing chemotherapy sensitivity (38). This evidence concerns the gene MTOR and familial pancreatic carcinoma.