MRC1 and neoplasm: Immunohistochemical profiling of xenografts revealed coordinated molecular alterations: HMGA2 silencing attenuated the expression of Ki-67 (IHC score 2.6 ± 0.2% vs 1.6 ± 0.4%, p<0.001), while modulating tumor-associated macrophages—CD86+ M1 density decreased by 83.2% (5.0 ± 3.7 vs 29.8 ± 7.3 cells/mm2, p<0.001), whereas CD206+ M2 infiltration increased 2.7-fold (42.0 ± 8.9 vs 15.6 ± 4.2 cells/mm2, p<0.001) (Figures 5D–H).