Intestinal biopsies often show an increase in the number of intraepithelial lymphocytes, giving an appearance similar to lymphocytic colitis, but this intestinal inflammation in CVID is distinguished from classic IBD by the absence of plasma cells in the chorion (44).In celiac disease, the histology is also similar, except for the absence of plasma cells in the chorion in CVID, but with the constant presence of CD3+ CD8+ intraepithelial T lymphocytes (45). This evidence concerns the gene CD8A and inflammatory bowel disease.