We also reasoned that through RA inflammatory conditions (such as raised levels of IFN‐γ, IL-6, and other cytokines), RA peripheral blood mononuclear cells (PBMC) may contain HLA-DR+ phenotypes (putative APC) of pathophysiologic relevance other than those meeting conventional dendritic cell and monocyte definitions. The gene discussed is IFNG; the disease is rheumatoid arthritis.