The HLA-DR+CD15+CD16+ phenotype contributed a mean of 1.3% (SD 2.85%) of the total APC compartment in RA, being more abundant than DC1 (0.17%), DC3 (0.34%), and similar to pDC (1.62%) but less frequent than DC2 or any of the monocyte subsets (Table 2). This evidence concerns the gene ZDHHC4 and rheumatoid arthritis.