Then, in order to further analyze the molecular mechanism of CPLX1 in promoting colorectal cancer development, we selected two colorectal cancer datasets, GSE17538 and GSE8671, and the “c2.cp.kegg_legacy.v2024.1.Hs.symbols” panel for enrichment analysis, and the results showed that CPLX1 was significantly and positively correlated with the “ERBB signaling pathway” (NES: 1.489, Nominal p-value: 0.021) and “Insulin signaling pathway (NES: 0.384, Nominal p-value: 0.014), which are able to promote the proliferation of cancer cells through the interaction of receptors (Figures 7E, F). This evidence concerns the gene EGFR and colorectal cancer.