Although the role of CPLX1 in regulating the immune microenvironment has not been clearly demonstrated, considering the functional similarity between CPLX1 and CPLX2, we speculated that CPLX1 might play a role in regulating the immune microenvironment in colorectal cancer, and therefore we performed immune cell infiltration analysis for evaluation. The gene discussed is CPLX2; the disease is colorectal cancer.