It was found that knockdown of CPLX1 in both RKO and HCT8 cells resulted in upregulation of MDA, Fe2+ content and the release of LDH (Figures 10N–P).Thus, CPLX1 may influence CRC progression and prognosis through its ability to regulate ferroptosis. This evidence concerns the gene CPLX1 and colorectal carcinoma.