DRD2 and Sepsis: Dopamine (DA), traditionally recognized for its role in the central nervous system (8), acts as an endogenous regulator of innate immunity through a complex interplay with various immune cells expressing dopamine receptors, primarily D1-like (DRD1 and DRD5) and D2-like (DRD2, DRD3, and DRD4) receptors (9), thereby significantly influencing the course and outcome of sepsis.