The FPR in vitro ligand T20/DP178 that originates from the highly conserved, c-terminally tryptophan rich region of gp41 was even used to develop a fusion inhibitor that could effectively block HIV infections in vitro and as an approved drug in vivo.35,36 Interestingly, the C-terminal part of T20/DP178 that is known as the membrane proximal region (MPR) has analogous sequences in a number of different viruses such as ebola virus, common cold coronaviruses and severe acute respiratory syndrome coronavirus (SARS-CoV) that interact with FPR1.37 The gene discussed is FPR1; the disease is HIV infectious disease.