Given the patient’s lack of other typical symptoms of MOGAD, such as optic neuritis, myelitis, acute disseminated encephalomyelitis (ADEM), cerebral monofocal or polyfocal deficits, brainstem or cerebellar deficits, and cerebral cortical encephalitis often accompanied by seizures, we concluded that the final diagnosis was a relapse of anti-LGI1 encephalitis. Here, LGI1 is linked to encephalitis.