CASP3 and neoplasm: A study of canine angiosarcoma (HSA) showed that YNBY significantly inhibited tumor cell growth in vitro (DEN, Fitz, SB cell lines), Furthermore, MTS assay, apoptosis assay (caspase-3/7 activity and TUNEL assay), and cell cycle analysis have confirmed the dose- and time-dependent anti-proliferative effects of YNBY (Wirth et al., 2016).